联系方式
邮箱：yanghj@hit.edu.cn
个人简介
1986-1990年：哈尔滨师范大学 生物学学士
1990-1993年：哈尔滨师范大学 细胞生物学硕士
1998-2001年：哈尔滨医科大学 遗传学博士
2001-2003年：哈尔滨医科大学 遗传学副教授
2003-2010年：韦恩州立大学 癌生物学博士后
2010年-至今：哈尔滨工业大学 生物学教授
Personal Profile
1986-1990: B.S. in Biology, Harbin Normal University
1990-1993: M.S. in Cell Biology, Harbin Normal University
1998-2001: Ph. D in Genetics, Harbin Medical University
2001-2003: Associate Professor in Biology , Harbin Medical University
2003-2010: Research Associate in Cancer Biology, the Barbara Ann Karmanos Cancer Institute, Wayne State University
2010-present: Professor in Biology, Harbin Institute of Technology
研究方向和领域
肿瘤细胞生物学
Cancer Cell Biology
研究内容
本研究室以胰腺癌吉西他滨耐药细胞为模型，探讨胰腺癌化疗耐药的关键调控分子及其作用的分子机制，为降低胰腺癌化疗耐药提供新的分子靶点。重点关注在胰腺肿瘤干细胞干性的形成与维持中发挥作用的长链非编码RNA，分析其作用方式及调控的信号通路。
Research Interests
Our laboratory uses gemcitabine-resistant models of pancreatic cancer to explore the fundamental molecules associated with the chemoresistance of pancreatic cancer and investigate the underlying molecular mechanisms, thereby provide a new molecular target for reducing the chemoresistance of pancreatic cancer. Specific areas of focus in the laboratory include exploring the long non-coding RNA that play a role in the formation and maintenance of pancreatic cancer stem cells. The function and regulated signal pathway of related lncRNA are dissected.
研究成果
1. Kai Li, Zhicheng Zhang, Yu Mei, Qingzhu Yang, Shupei Qiao, Cheng Ni, Yao Yao, Xinyuan Li, Mengmeng Li, Dongdong Wei, Wangjun Fu, Xuefei Guo, Xuemei Huang, Huanjie Yang. Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion via NF-κB inhibition. Theranostics 2021; 11(7): 3196-3212.
2. Qingzhu Yang, Li Kai, Xuemei Huang, Chen Zhao, Yu Mei, Xinyuan Li, Lin Jiao, Huanjie Yang *. LncRNA SLC7A11-AS1 promotes chemoresistance by blocking SCFβ-TRCP-mediated degradation of NRF2 in pancreatic cancer. Mol Ther Nucleic Acids. 2020 Mar 6;19:974-985.
3. Wang H, Li K, Mei Y, Huang X, Li Z, Yang Q, Yang H*. Sp1 Suppresses miR-3178 to Promote the Metastasis Invasion Cascade via Upregulation of TRIOBP. Mol Ther Nucleic Acids. 2018 Sep 7;12:1-11.
4. Yuran Gao, Zhicheng Zhang, Kai Li, Liying Gong, Qingzhu Yang, Xuemei Huang, Chengcheng Hong, Mingfeng Ding, Huanjie Yang*. Linc-DYNC2H1-4 promotes EMT and CSC phenotypes by acting as a sponge of miR-145 in pancreatic cancer cells. Cell Death & Dis. 2017 Jul 13;8(7):e2924.
开设的课程
生物专业导论
Introduction to Biology
细胞死亡
Cell Death
科研设计与论文写作
Scientific and Technical Research Design and Paper Writing
肿瘤细胞分子生物学进展专题
Advances in Molecular Cancer Biology
生命科学基础与应用
Foundation and Application of Life Science
教师个人主页链接
http://homepage.hit.edu.cn/yanghuanzhi
