联系方式
联系电话：18611681275
所在单位：军事科学院军事医学研究院
个人简介
1993-1997 年：烟台大学化学生物理工学院 生物化学 学士
1997-2000 年：山东大学生命科学学院 细胞生物学 硕士
2000-2003 年：军事医学科学院 细胞生物学 博士
2003-2005 年：军事医学科学院 助理研究员
2005-2008 年：军事医学科学院 副研究员
2008-2017 年：军事医学科学院 研究员
2017-至今：军事科学院军事医学研究院 研究员
兼任：中国生物化学与分子生物学会理事、副秘书长（2023-2027）；中国细胞生物学学会理事（2015-2023）；中国生物物理学会理事（2009-2021）
Personal Profile
1993-1997: Yantai University, School of Chemical and Biological Engineering, BSc in Biochemistry
1997-2000: Shandong University, School of Life Sciences, MSc in Cell Biology
2000-2003: Academy of Military Medical Sciences, PhD in Cell Biology
2003-2005: Academy of Military Medical Sciences, Assistant Researcher
2005-2008: Academy of Military Medical Sciences, Associate Researcher
2008-2017: Academy of Military Medical Sciences, Researcher
2017-: Academy of Military Medical Sciences, Researcher
Concurrent: Director and Deputy Secretary-General of Chinese Society of Biochemistry and Molecular Biology (2023-2027); Director of Chinese Society for Cell Biology (2015-2023); Director of Biophysical Society of China (2009-2021)
研究方向和领域
肿瘤生物学、空间生物学
研究内容
1、泛素化修饰：探索泛素化酶、去泛素化酶、泛素应激小体等蛋白质机器与发育、疾病发生的关系，利用蛋白质组学、分子生物学、细胞生物学等技术绘制泛素化组修饰图谱，发掘疾病诊断标志物，研发治疗新策略。
2、水熊虫抗逆机制及应用：在国内首创水熊虫实验室繁育体系，致力于解析水熊虫非凡的抗逆能力分子基础，研发抗辐射等新方法、新技术、新材料。
Research Interests (word limit 150)
1. Ubiquitination Modification: Explore the relationship between protein machines (e.g., ubiquitin ligases, deubiquitinating enzymes, Ubstressome) and development/disease occurrence. Employ proteomics, molecular biology, cell biology and other technologies to map the ubiquitinome modification profile, identify disease diagnostic biomarkers, and develop novel therapeutic strategies.
2. Tardigrade Stress Resistance Mechanisms and Applications: Pioneered the establishment of a scalable laboratory culture system for tardigrades in China. Focus on elucidating the molecular basis of their extraordinary stress resistance, and develop novel radiation-resistant methods, technologies, and materials.
研究成果 (about 10)
1. Yong Zhang#, Yesheng Fu#, Lihua Qiang#, Mengyuan Zhao, Zhe Lu, Zhuo Zhao,Guoping Chen, Zehui Lei, Qiyao Chai, Pupu Ge, Bingxi Li, Jing Wang, Cui Hua Liu*, Lingqiang Zhang*.Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity. Advanced Science, 2025 Jul 12;12(28):e2417660
2. Zhiqiang Peng#, Wei Fang#, Bo Wu#, Ming He#, Shaohua Li#, Jun Wei, Yang Hao, Lujia Jin, Mingqiu Liu, Xin Zhang, Yange Wei, Yingwei Ge, Yinghua Wei, Haili Qian, Yangjun Zhang, Junyi Jiang, Zhijie Chang, Yu Rao*, Xueli Zhang*, Chunping Cui*, Lingqiang Zhang*. Targeting Smurf1 to block PDK1–Akt signaling in KRAS-mutated colorectal cancer. Nature Chemical Biology, 2025 Jan, 21(1):59-70
3. Lei Li#, Zhengping Ge#, Shihao Liu#, Kun Zheng#, Yaqi Li#, Kaiqi Chen#, Yesheng Fu#, Xiaoguang Lei, Zeling Cui,Yifan Wang, Jin Huang, Yanyan Liu , Mingwang Duan, Zimei Sun, Jun Chen, Liangwei Li, Pan Shen, Guibin Wang ,Junmiao Chen, Ruochong Li, Chaoran Li, Zhixiang Yang, Yifan Ning, Arong Luo, Baoyu Chen, Inge Seim, Xin Liu, Fei Wang, Yishan Yao, Fusheng Guo , Maojun Yang, Cui Hua Liu, Guangyi Fan*, Lizhi Wang*,Dong Yang*, Lingqiang Zhang*.Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade. Science，2024 Oct 25;386(6720):eadl0799
4. Yingwei Ge#, Lijie Zhou#, Yesheng Fu#, Lijuan He, Yi Chen, Dingchang Li, Yuping Xie, Jun Yang, Haitao Wu, Hongmiao Dai, Zhiqiang Peng, Yong Zhang, Shaoqiong Yi, Bo Wu, Xin Zhang, Yangjun Zhang, Wantao Ying, Chun-Ping Cui, Cui Hua Liu*, Lingqiang Zhang*. Caspase-2 is a condensate-mediated deubiquitinase in protein quality control. Nature Cell Biology, 2024 Nov;26(11):1943-1957
5. Hongmiao Dai#, Bo Wu#, Yingwei Ge, Yang Hao, Lijie Zhou, Ruolin Hong, Jinhao Zhang, Wenli Jiang, Yuting Zhang, Hongchang Li*, Lingqiang Zhang*. Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer. Cell Reports，2024 Jul 23;43(7):114487
6. Yesheng Fu#, Lei Li#, Xin Zhang#, Zhikang Deng#, Ying Wu#, Wenzhe Chen, Yuchen Liu, Shan He, Jian Wang, Yuping Xie, Zhiwei Tu, Yadi Lyu, Yange Wei, Shujie Wang, Chun-Ping Cui, Cui Hua Liu*, Lingqiang Zhang*. Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis. Nature Communications, 2024 Apr 6;15(1): 2974
7. Yesheng Fu, Hongtian Wang, Hongmiao Dai, Qiong Zhu, Chun-Ping Cui, Xiaoxuan Sun, Yanchang Li, Zhikang Deng, Xuemei Zhou, Yingwei Ge, Zhiqiang Peng, Chao Yuan, Bo Wu, Xi Yang, Rongyu Li, Cui Hua Liu*, Fuchu He*, Wenyi Wei*, Lingqiang Zhang*. OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin. Molecular Cell, 2021; 81(15): 3187-3204
8. Ping Xie#*, Zhiqiang Peng#, Yujiao Chen, Hongchang Li, Mengge Du, Yawen Tan, Xin Zhang, Zhe Lu, Chun-Ping Cui, Cui Hua Liu, Fuchu He, Lingqiang Zhang*. Neddylation of PTEN regulates its nuclear import and promotes tumor development. Cell Research. 2021, 31(3): 291-311
9. Lin Yuan#, Yanrong Lv#, Hongchang Li#, Haidong Gao, Shanshan Song, Yuan Zhang, Guichun Xing, Xiangzhen Kong, Lijing Wang, Yang Li, Tao Zhou, Daming Gao, Zhi-Xiong Xiao, Yuxin Yin, Wenyi Wei, Fuchu He, Lingqiang Zhang*. Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nature Cell Biology, 2015, 17(9): 1169-1181
10. Chao Liang#, Baosheng Guo#, Heng Wu#, Ningsheng Shao, Defang Li, Jin Liu, Lei Dang, Cheng Wang, Hui Li, Shaohua Li, Wing Ki Lau, Zhijun Yang, Cheng Lu, Xiaojuan He, D. W. T. Au, Xiaohua Pan, Baoting Zhang, Changwei Lu, Hongqi Zhang, Kinman Yue, Airong Qian, Peng Shang, Jiake Xu, Lianbo Xiao, Zhaoxiang Bian, Weihong Tan, Zicai Liang, Fuchu He, Lingqiang Zhang*, Aiping Lu*, Ge Zhang*. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nature Medicine, 2015, 21(3): 288-294
