联系方式
个人简介
1981-1985 年：北京大学 遗传学 学士
1985-1987 年：中国农业科学院 遗传学 硕士
1987-1989 年：中国农业科学院 遗传学 博士
1989-1992 年：美国德克萨斯 A&M 大学 博士后
1992-2008 年：美国 Emory 大学医学院、堪萨斯大学等 博士后、讲师、助理教授、副教授
2008-2023 年：首都医科大学附属北京安贞医院主任、副所长、教授、研究员
2023 年 - 至今：河南省医学科学院生物治疗研究所所长、二级教授
Personal Profile
1981-1985: Peking University Bachelor in Genetics
1985-1987: Chinese Academy of Agricultural Sciences Master in Genetics
1987-1989: Chinese Academy of Agricultural Sciences PhD in Genetics
1989-1992: Texas A&M University, USA Postdoctoral Fellow
1992-2008: Emory University School of Medicine, University of Kansas, etc., USA Postdoctoral Fellow, Lecturer, Assistant Professor, Associate Professor
2008-2023: Beijing Anzhen Hospital Affiliated to Capital Medical University Director, Deputy Director, Professor, Researcher
2023- : Institute of Biological Therapy，Henan Academy of Innovations in Medical Science Director, Second-Class Professor
研究方向和领域(肿瘤生物学、空间生物学代谢生物学、微生物与免疫学、发育生物学、计算生物学与生物信息学、神经生物学、生物医学工程 可以多选)
生物学、生理学、心血管疾病的防诊治及转化研究、代谢生物学、生物医学工程
研究内容（word limit 150）
长期聚焦心血管急危重症“难识别、难干预” 难题，从事病因学及临床转化研究。提出 “炎症风暴导致心血管损伤” 病因理论，揭示心力衰竭等疾病的炎症微环境调控分子机制，发掘主动脉瘤等疾病的预警生物标志物，建立分子分型诊疗标准。开发生物标志物检测体系与代谢解读方案，搭建基础 - 临床 - 转化平台，发现新致病基因与治疗靶点，构建快速诊断策略及新型治疗方案，助力疾病早期预警与精准诊治。
Research Interests (word limit 150)
Prof. Du has long focused on the bottlenecks of difficult identification and intervention in acute and critical cardiovascular diseases, engaging in etiological and clinical transformation research. He proposed the etiological theory of inflammatory storm-induced cardiovascular injury, revealed the molecular mechanism of inflammatory microenvironment regulation in heart failure and other diseases, identified early warning biomarkers for aortic aneurysm, and established molecular typing diagnosis and treatment standards. He developed biomarker detection systems and metabolic interpretation schemes, built a basic-clinical-translational platform, discovered new pathogenic genes and therapeutic targets, and constructed rapid diagnosis strategies and novel treatment regimens to support early warning and precision medicine of diseases.
研究成果（about 10）
1. macrophage card9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression. Signal Transduction and Targeted Therapy, 8 (1):394, 2023 年 8 月，通讯作者
2. variants of focal adhesion scaffold genes cause thoracic aortic aneurysm. Circulation Research, 128 (1):8-23, 2021 年 1 月，通讯作者
3. Therapeutic and prognostic Significance of Arachidonic Acid in Heart Failure. Circulation Research, 130 (7):1056-1071, 2022 年 4 月，通讯作者
4. Platelet and Erythrocyte Membranes Coassembled Biomimetic Nanoparticles for Heart Failure Treatment. ACS Nano, 18 (39):26614-26630, 2024 年 10 月，通讯作者
5. opg/trail ratio as a predictive biomarker of mortality in patients with type a acute aortic dissection. Nature Communications, 12 (1):3401, 2021 年 6 月，通讯作者
6. S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure. Nature Communications, 15 (1):2701, 2024 年 5 月，通讯作者
7. il-33 facilitates fibro-adipogenic progenitors to establish the pro-regenerative niche after muscle injury. Advanced Science, 11 (35):e2405299, 2024 年 9 月，通讯作者
8. Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function. Small, 16 (4):e1905925, 2020 年 6 月，通讯作者
9. rapid and multi-target genotyping of helicopter pylori with digital microfluidics. Biosensors & Bioelectronics, 256, 2024 年 7 月，通讯作者
10. Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration. Journal of Cachexia, Sarcopenia and Muscle, 11 (5):1291-1305, 2020 年 10 月，通讯作者
