联系方式
邮箱:wangxingwen@hit.edu.cn
个人简介
2009.09-2013.07，哈尔滨师范大学，生命科学与技术学院，学士
2013.09-2015.06，哈尔滨工业大学，生命科学与技术学院，硕士
2015.09-2019.07，哈尔滨工业大学，生命科学与技术学院，博士
2019.07-至今，哈尔滨工业大学，机电工程学院，博士后
2019.07-2021.12，哈尔滨工业大学，生命科学与技术学院，助理研究员
2022.01-至今，哈尔滨工业大学，生命科学与技术学院，副研究员
研究方向和领域
肿瘤细胞生物学
Tumor Cell Biology
研究内容
Research Interests
1. Molecular mechanism of tumor metastasis and drug resistance
2. Study on the expression of non-coding RNA and its regulatory mechanism in tumor
研究成果
1. Xingwen Wang, Li Li, Kunming Zhao, Qingyu Lin, Huayi Li, Xuting Xue, Wenjie Ge, Hongjuan He, Dong Liu, Hui Xie, Qiong Wu and Ying Hu.A novel LncRNAHITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumorgrowth.Cell Death and Differentiation, 2020, 27(4): 1431-1446.
2. Xingwen Wang#, Shanliang Zheng#, Fan Yang, Wenxin Zhang, Dong Zhao, Xuting Xue, Qingyu Lin, Yunfei He, Guohong Hu and Ying Hu. LncRNA HITT inhibits metastasis by attenuating Rab5-mediated endocytosis in lung adenocarcinoma. Molecular Therapy, 2022, 8;S1525-0016(22)00014-4.
3. Xingwen Wang, Yudong Wang, Li Li, Xuting Xue, Hui Xie, Huaxing Shi and Ying Hu. A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia.Oncogene, 2020, 39(9): 1860-1874.
4. Xingwen Wang, Dong Zhao, Hui Xie and Ying Hu. Interplay of long non-coding RNAs and HIF-1α: A new dimension to understanding hypoxia-regulated tumor growth and metastasis.Cancer Letters. 2021,499:49-59.
5. Xingwen Wang, Miao Yu, Kunming Zhao, Mengmeng He, Wenjie Ge, Yuhui Sun, Yihua Wang, Haizhu Sun and Ying Hu.Upregulation of MiR-205 under hypoxia promotes epithelial-mesenchymal transition by targeting ASPP2. Cell Death and Disease， 2016 Dec 8;7(12): e2517.
6. Xingwen Wang, Yiwei Cheng, YiFu Zhu, Huayi Li, Wenjie Ge, Xiaoliang Wu, Kunming Zhao, Jinyang Yuan, Zhenglin Li, Shijian Jiang, Zhengbin Han, Qinghua Jiang, Qiong Wu, Tao Liu, Cheng Zhang, Miao Yu and Ying Hu, Epigenetic Silencing of ASPP1 confers 5-FU resistance in clear cell renal cell carcinoma by preventing p53 activation. International Journal of Cancer, 2017.141(7):1422-1433.
7. Huayi Li#, Xingwen Wang#, Cheng Zhang, Yiwei Cheng, Miao Yu, Kunming Zhao, Wenjie Ge, Anyong Cai, Yao Zhang, Fengtong Han, Ying Hu. HDAC1-induced epigenetic silencing of ASPP2 promotes cell motility, tumour growth and drug resistance in renal cell carcinoma, Cancer Letters. 2018,432:121-131.
8. Wenjie Ge#, Kunming Zhao#, Xingwen Wang, Huayi Li, Miao Yu, Mengmeng He, Xuting Xue, Yifu Zhu, Cheng Zhang, Yiwei Cheng, Shijian Jiang and Ying Hu, iASPP Is an Antioxidative Factor and Drives Cancer growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding, Cancer Cell, 2017,32,1–13.
9. Shanliang Zheng, Dong Zhao, Guixue Hou, Song Zhao, Wenxin Zhang, Xingwen Wang, Li Li, Liang Lin, Tie-Shan Tang, Ying Hu. iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance. Proc Natl Acad Sci U S A. 2022,119(6):e2111380119.
10.Kunming Zhao, Xingwen Wang, Xuting Xue, Li Li, Ying Hu*. A long non-coding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers. PLos Biology.18(3):e3000666. 2020.
11.Dong Zhao, Shanliang Zheng, Xingwen Wang, Hao Liu, Kunming Zhao, Li Li, Ying Hu. iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation. Oncogene, 2022.
12.Wenjie Ge, Yudong Wang, Shanliang Zheng, Dong Zhao, Xingwen Wang, Xiaoshi Zhang, Ying Hu. Nuclear iASPP determines cell fate by selectively inhibiting either p53 or NF-κB. Cell Death Discovery. 2021, 7(1):195.
教师个人主页链接
http://homepage.hit.edu.cn/wangxingwen
