联系方式
邮箱：263276998@qq.com
个人简介
1997.9-2001.7：东北师范大学化学学院，学士
2001.9-2004.7:东北师范大学化学学院，无机化学，硕士
2004.9-2007.7:中国科学院化学研究所，物理化学，博士
2007.7-2011.12:哈尔滨工业大学，生命科学与技术学院，讲师
2012.1至今:哈尔滨工业大学，生命科学与技术学院，副教授
Personal Profile
1997.9-2001.7, School of Chemistry, Northeast Normal University, Bachelor
2001.9-2004.7, School of Chemistry, Northeast Normal University, Inorganic Chemistry, Master
2004.9-2007.7, Institute of Chemistry, Chinese Academy of Science, Physical chemistry, Doctor
2007.7-2011.12, School of Life Science and Technology, Institute of Technology, Lecture
2012.1 to present, School of Life Science and Technology, Institute of Technology, Associate Professor
研究方向和领域
生物传感
Biosensors
纳米诊疗试剂
Nano-theranostic agents
研究内容
1. 基于纳米探针构建生物传感器，用于检测重金属离子、农药等环境污染物以及体液中与人体疾病相关的离子、分子标志物等生化物质。
2. 构建具有声、光、磁等多功能的造影剂，同时研究具有医学诊断和治疗作用的多功能诊疗一体化试剂。
Research Interests
1. Developing biosensors based on nanoprobes for detecting various environmental pollutants such as heavy metal ions and pesticide residue as well as some biochemical substances such as ions and molecular markers in body fluids.
2. The construction of multi-functional contrast agents with ultrasound, light and magnetic properties, and the research of multi-functional theranostic agents with diagnostic and therapeutic effects.
研究成果
1. Caixin Guo*, Jinliang Wang, Jing Cheng, Colorimetric sensing of copper (Ⅱ) ions based on the inhibition of biocatalytic growth of gold nanoparticles, Microchemical Journal 2020,157,105015.
2. Zhaohua Miao, Caixin Guo, Zhenglin Li, Yushen Jin, Hengte Ke, Zhifei Dai, Fabrication of a multimodal microbubble platform for magnetic resonance, ultrasound and fluorescence imaging application, Journal of Nanoscience and Nanotechnology, 2016, 16, 2301-2306.
3. Caixin Guo, Yushen Jin, and Zhifei Dai, Multifunctional ultrasound contrast agents for imaging guided photothermal therapy, Bioconjugate chem. 2014, 25, 840-854.
4. Xiuli Yue*, Caixin Guo, Yuanmiao Jing, Fang Ma, Free-standing liposomal nanohybrid cerasomes as ideal materials for cupric ions sensing, Analyst, 2012, 137, 2027-2031.
5. Caixin Guo, Jinliang Wang, Jing Cheng, Zhifei Dai, Determination of trace copper ions with ultrahigh sensitivity and selectivity utilizing CdTe quantum dots coupled with enzyme inhibition, Biosensor and Bioelectronics, 2012, 36, 69-74. （代表性成果）
6. Caixin Guo, Like Zeng, Shaoqin Liu, Qi Chen, Zhifei Dai, Xiaoyi Wu, In Vitro Evaluation and Finite Element Simulation of Drug Release from Polydiacetylene-Polyethylene Glycol Stearate Nanovesicles, J. Nanosci. Nanotech. 2012, 12, 245-251.
7. Caixin Guo, Jinliang Wang, Zhifei Dai, Selective content release from light-responsive microcapsules by tuning the surface plasmon resonance of gold nanorods, Microchimica Acta, 2011, 173, 375-382.（代表性成果）
8. Hengte Ke, Jinrui Wang, Zhifei Dai, Yushen Jin, Enze Qu, Zhanwen Xing, Caixin Guo, Xiuli Yue, Jibin Liu, Gold nanoshelled microcapsules: a theranostic agent for ultrasound contrast imaging and photothermal therapy, Angew. Chem. Int. Edit., 2011, 50, 3017-3021 (IF 13.455). Hot paper. Highlighted by Nature Materials.
9. Hengte Ke, Jinrui Wang, Zhifei Dai, Yushen Jin, Enze Qu, Zhanwen Xing, Caixin Guo, and Xiuli Yue, Bifunctional gold nanorod-loaded polymeric microcapsules for both contrast-enhanced ultrasound imaging and photothermal therapy, Journal of Materials Chemistry, 2011, 21, 5561-5564.
10. Caixin Guo, Shaoqin Liu, Zhifei Dai, Chang Jiang, Wenyuan Li, Polydiacetylene vesicles as a novel drug sustained-release system, Colloids and Surfaces B: Biointerfaces 2010, 76, 362-365.
11. Caixin Guo, Shaoqin Liu, Chang Jiang, Wenyuan Li, Zhifei Dai, Hiroe Fritz, Xiaoyi Wu, A Promising Drug Controlled-Release System Based on Diacetylene/Phospholipid Polymerized Vesicles, Langmuir 2009, 25, 13114-13119.（代表性成果）
12. Renzhe Zhang, Caixin Guo, Long Jiang, Tao Liu, The Fluorescence Recovery of Polydiacetylene/Fluorophore Vesicles by Interaction with Cetyltrimethylammonium Bromide，Journal of Nanoscience and Nanotechnology 2009, 9, 990-994.
13. Caixin Guo, Paul Boullanger, Long Jiang, Tao Liu, One-Step Immobilization of Dodecanethiol/Glycolipid Vesicles onto Gold Electrode: Amperometric Detection of Concanavalin A，Colloids and Surfaces B: Biointerfaces 2008, 62, 146-150.
14. Caixin Guo, Paul Boullanger, Long Jiang, Tao Liu, Highly Sensitive Gold Nanoparticles Biosensor Chips Modified with a Self-assembled Bilayer for Detection of Con A, Biosensor and Bioelectronics 2007, 22, 1830-1834.（代表性成果）
15. Caixin Guo, Paul Boullanger, Long Jiang, Tao Liu, Colorimetric Detection of WGA in Carbohydrate-functionalized Polydiacetylene Langmuir–Schaefer Films, Colloids and Surfaces A: Physicochem. Eng. Aspects 2007, 293, 152-156.
16. Caixin Guo, Renzhe Zhang, Long Jiang, Tao Liu，Investigation on the temperature effect of a mixed vesicle composed of polydiacetylene and BODIPY 558，Colloids and Surfaces B: Biointerfaces 2007, 60, 41–45.
17. Caixin Guo, Paul Boullanger, Tao Liu, Long Jiang, Size Effect of Polydiacetylene Vesicles Functionalized with Glycolipids on Their Colorimetric Detection Ability, J. Phys. Chem. B 2005, 109, 18765-18771.（代表性成果）
18. Caixin Guo, Minhua Cao, Changwen Hu, Synthesis and Characterization of Dy(OH)3 and Dy2O3 Nanotubes, J. Nanosci. Nanotech. 5, (2005), 184-187
19. Caixin Guo, Minhua Cao, Changwen Hu, A Novel and Low-temperature Hydrothermal Synthesis of SnO2 Nanorods, Inorg. Chem. Commun. 7, (2004), 929-931.
20. Minhua Cao, Caixin Guo, Yanjuan Qi, Changwen Hu, Enbo Wang, Shape and Size Control of ZnO Nanostructures via a Simple Solution Route, J. Nanosci. Nanotech. 4, (2004), 829-832.
21. Minhua Cao, Yonghui Wang, Caixin Guo, Yanjuan Qi, Changwen Hu, Enbo Wang, A simple route towards CuO nanowires and nanorods, J. Nanosci. Nanotech. 2004, 4 (7), 824-828.
22. Minhua Cao, Yonghui Wang, Caixin Guo, Yanjuan Qi, Changwen Hu, Preparation of ultrahigh-aspect-ratio hydroxyapatite nanofibers in reverse micelles under hydrothermal conditions, Langmuir, 2004, 20, 4784-4786.
23. Danfeng Li, Changzhi Gu, Caixin Guo, Changwen Hu, The effects of ambient gases on the surface resistance of polyoxometalate/TiO2 film, Chem. Phys. Lett., 2004, 385 (1-2), 55-59.
24. Yonghui Wang, Caixin Guo, Y. W. Chen, Changwen Hu, W. H. Yu, Self-assembled Multilayer Films Based on a Keggin-type Polyoxometalate and Polyaniline, J. Colloid and Interface Science, 264, (2003), 176.
专利
郭彩欣，戴志飞，王金梁，成晶, 高灵敏度的铜离子检测用荧光生物传感器及其检测方法, ZL201210085632.3.
开设的课程
纳米药物学
Nanomedicine
生物医学检测及传感器
Biomedical Detection and Sensor
教师个人主页链接
http://homepage.hit.edu.cn/guocaixin
