联系方式
邮箱：yuweizhu@hit.edu.cn
个人简介
2005-2009年：辽宁大学 生物化学与分子生物学学士
2009-2014年：中国科学技术大学 生物化学与分子生物学博士
2017-2019年：哈尔滨工业大学 生物医学工程学博士后
2020年-：哈尔滨工业大学 生物化学与分子生物学副教授
研究方向和领域
CRISPR-Cas system and Anti-CRISPR proteins
研究内容
My focus is on determining the structures of DNA/RNA-protein complexes using X-ray diffraction and Cryo-EM.
通过X-射线晶体学及冷冻电镜等结构生物学手段解析蛋白质与核酸复合物的结构
研究成果
1. Zhang, K†., Wang, S†., Li, S†., Zhu, Y†., Pintilie, GD., Mou, T., Schmid, MF., Huang, Z., Chiu W. Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas complex revealed by cryo-EM. Proc Natl Acad Sci U S A, 2020 Mar 13. (Co-first author)
2. Dong, D†., Zheng, L†., Lin, J†., Zhang, B., Zhu, Y., Li, N., Xie, S., Wang, Y., Gao, N., Huang, Z. Structural basis of assembly of the human T cell receptor-CD3 complex. Nature, 2019 Sep;573(7775):546-552.
3. Zhu, Y., Huang, Z. Recent advances in structural studies of the CRISPR-Cas-mediated genome editing tools. National Science Review, Volume 6, Issue 3, May 2019, Pages 438–451.
4. Dong, L†., Guan, X†., Li, N†., Zhang, F., Zhu, Y., Ren, K., Yu, L., Zhou, F., Han, Z., Gao, N., Huang, Z. An anti-CRISPR protein disables type V Cas12a by acetylation. Nat Struct Mol Biol. 2019 Apr;26(4):308-314.
5. Guo, M†., Ren, K†., Zhu, Y†., Tang, Z., Wang, Y., Zhang, B., Huang, Z. Structural insights into a high fidelity variant of SpCas9. Cell Res. 2019 Mar;29(3):183-192.(Co-first author)
6. Zhu, Y., Zhang, F., Huang, Z. Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins. BMC biology, 2018 Mar 19;16(1):32.
7. Dong, D†., Guo, M†., Wang, S†., Zhu, Y., Wang, S., Xiong, Z., Yang, J., Xu, Z., Huang, Z. Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein. Nature, 2017 Jun 15;546(7658):436-439.
8. Wu, D†., Guan, X†., Zhu, Y†., Ren, K., Huang, Z. Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA. Cell Res, 2017 May;27(5):705-708. (Co-first author)
