联系方式
邮箱：hanfang@hit.edu.cn
个人简介
1996-2000年：东北农业大学 生物技术 学士
2000-2003年：东北农业大学 分子免疫学 硕士
2003-2006年：东北农业大学 分子遗传学 博士
2015-2021年：哈尔滨工业大学 生命科学与技术学院 副教授
2011-2013年：美国A&M大学健康医学中心 访问学者
Personal Profile
1996-2000: Bachelor of Biotechnology, Northeast Agricultural University
2000-2003: Master of Molecular Immunology, Northeast Agricultural University
2003-2006: Ph.D. in molecular genetics, Northeast Agricultural University
2015-2021: Associate Professor, School of Life Science and Technology, Harbin Institute of Technology
2011-2013: Visiting Scholar, A&M University Health Medical Center, USA
研究方向和领域
肿瘤细胞生物学
Tumor cell biology
肿瘤细胞糖代谢
Tumor cell glucose metabolism
研究内容
主要从事肿瘤细胞分子生物学、肠道微环境稳态调控机制、细胞的辐射损伤与修复和肿瘤诊断的分子标记物研究，实现生物医学理论基础研究技术转化。
1.发现多功能蛋白MARVELD1：高度保守，影响细胞运动迁移能力，影响小鼠出生后小肠发育以及功能细胞的分化和发育，调控DNA损伤与修复功能。
2.发现多功能蛋白MARVELD1影响肿瘤细胞糖代谢：研究肿瘤细胞葡萄糖代谢稳态失衡以及重编程过程的调控机制，并研究MARVELD1影响细胞葡萄糖代谢的分子机制。
3.应对新型冠状病毒疫情，推进医工交叉，研发核酸检测一体化设备与试剂，快速实现技术转化。
Research Interests
Associate professor FANG HAN's research focuses on tumor cell biology, Tumor cell glucose metabolism, molecular diagnosis of diseases and the transformation of biomedical technology.
1. The research team found that the multifunctional protein MARVELD1 was highly conserved, affecting the movement and migration of cells, the differentiation and development of small intestine functional cells, and regulating DNA damage and repair functions.
2. The research team found that the multifunctional protein MARVELD1 affected glucose metabolism in tumor cells: Study the imbalance of glucose metabolism homeostasis and the regulation mechanism of reprogramming process in tumor cells; Study the molecular mechanism of MARVELD1 affecting glucose metabolism.
3. In response to the Novel Coronavirus outbreak, the research team have promoted the integration of medical and industrial, and developed integrated nucleic acid testing equipment and reagents, so as to achieve technological transformation.
研究成果
近五年内承担或主持科研项目5项，其中包括：中国工程院防疫应急重大仪器研究项目、国家自然科学基金面上项目、黑龙江省自然科学基金面上项目、黑龙江省自然科学基金联合引导项目等。近五年主要代表性科研论文：
1. PengDou,Yiqun Li, Haoxiu Sun, WanqiuXie, Xiaoqing Zhang, Xiaohan Zhang, Dandan Zhang, ShupeiQiao, Yanpeng Ci, HuanNie, Fang Han* and Yu Li* C1orf109L binding DHX9 promotes DNA damage depended on the R-loop accumulation and enhances camptothecinchemosensitivity，cell proliferation，dio：10.1111/cpr.12875. 2020.（并列通讯作者）
2. Chunbin Zhang, Fang Han, Ming Shi, Haoxiu Sun, Yiqun Li, Yanpeng Ci, Yuanfei Yao, Peng Dou, Muhammad luqman Akhtar, Huan Nie, Jie He, Li Y*. MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system. Mol Carcinog, 08;58(8):1410-1426, 2019.（并列第一作者）
3. Zongjun Liu, Tuo Li, Fang Han, You Wang,* Yang Gan,* Junhui Shi, Tianran Wang, Muhammad Luqman Akhtar, and Yu Li*.A Cascade-Reaction Enabled Synergistic Cancer Starvation/ROS-mediated /chemotherapy with Enzyme Modified Fe-based MOF. Biomater Sci,7(9): 3683-3692, 2019. （并列第一作者）
4. Weizhe Liu, Fang Han, Shuai Qu, Yuanfei Yao, Jianxiang Zhao, Muhammad Luqman Akhtar, Yanpeng Ci, Hao Zhang, Hongfei Li, Yufang Zhao, Lei Yue, Yao Zhang, Changlin Wang*&Yu Li*. MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development. Cell Death & Disease, 9: 999, 2018.
5. Chen Y, Zhang H, Han F, Yue L, Qiao C, Zhang Y, Dou P, Liu W, Li Y. The depletion of MARVELD1 leads to murine placenta accreta via integrin β4-dependent trophoblast cell invasion. J Cell Physiol, 2018, 233(3): 2257-2269
开设的课程
免疫学
Immunology
分子免疫学
Molecular Immunology
生命科学基础与应用
Fundamentals and Applications of Life Sciences
教师个人主页链接
http://homepage.hit.edu.cn/FANGHAN
