刘川鹏

发布者:张宁发布时间:2021-08-20浏览次数:2185

联系方式   

邮箱:liucp74@hotmail.com

 

个人简介

1993-1997年:吉林大学理学学士Jilin University, B.Sc.

1997-2000年:吉林大学理学硕士Jilin University, M.Sc

2000-2004年:中科院生物物理研究所理学博士Institute of Biophysics, CAS, Ph.D.

2005-2007年:宾西法尼亚大学理学博士后University of Pennsylvania, Postdoc

2008-2021年:哈尔滨工业大学理学副教授Harbin Institute of Technology, Assoc. Prof.

 

研究方向和领域

分子伴侣

Chaperone

酶学

Enzymology


研究内容

分子伴侣构效关系以及对蛋白内稳态的影响作用机制;蛋白修饰酶生理功能及其抑制剂开发

The relationship of structure and function of chaperones and their roles in proteostasis maintenance;the physiological roles of protein modifiers and their inhibitor

 

研究成果

1.**Zhongya Sun#; Hao Zhang#; Yuanyuan Zhang#; Liping Liao#; Wen Zhou#; Fengcai Zhang; Fulin Lian; Jing Huang; Pan Xu; Rukang Zhang; Wenchao Lu; Mingrui Zhu; Hongru Tao; Feng Yang; Hong Ding; Shijie Chen; Liyan Yue; Bing Zhou; Naixia Zhang; Minjia Tan; Hualiang Jiang; Kaixian Chen; Bo Liu*; Chuanpeng Liu*; Yongjun Dang*; Cheng Luo*; Covalent inhibitors allosterically block the activation of Rho family proteins and suppress cancer cell invasion, Advanced Science,2020, 7(14): 2000098

2.Feng-cai Zhang#; Zhong-ya Sun#; Li-ping Liao; Yu Zuo; Dan Zhang; Jun; Wang; Yan-tao Chen; Sen-hao Xiao; Hao Jiang; Tian Lu; Pan Xu; Li-yan Yue;  Dao-hai Du; Hao Zhang; Chuan-peng Liu*; Cheng Luo*; Discovery of novel CBP. bromodomain inhibitors through TR-FRET-based high-throughput screening, acta pharmacologica sinica, 2020, 41(2): 286-292.

3.**Dongjie Fan, Shunan Cao, Qiming Zhou, You Zhang, Lei Yue, Chang Han, Bo Yang, Yu Wang, Zhuo Ma, Lingxiang Zhu, Chuanpeng Liu;Exploring the roles of substrate-binding surface of chaperone site in the chaperone activity of trigger factor;The FASEB Journal; 2018, 32(12): 6655-6665

4.Dongjie Fan, Lushan Liu, Lingxiang Zhu, Fang Peng, Qiming Zhou*, Chuanpeng Liu*. (2017) Global Analysis of the Impact of Deleting Trigger Factor on the Transcriptome Profile of Escherichia coliJ.Cell. Biochem. 118(1): 141-153

5.Dongjie Fan, Chuanpeng Liu*, Lushan Liu, Lingxiang Zhu, Fang Peng, Qiming Zhou*. (2016) Large-scale gene expression profiling reveals physiological response to deletion of chaperone dnaKJ in Escherichia coli. Microbiol. Res. 186-187: 27-36

 

开设的课程

分子生物学

Molecular Biology

生物大分子结构与功能

Structure and Function of Biomacromolecule

分子生物学进展

Progress in Molecular Biology



教师个人主页链接

http://homepage.hit.edu.cn/liuchuanpeng