联系方式
邮箱：lilili@hit.edu.cn
个人简介
教育经历:
2000年 获吉林大学临床医学学士学位（医学）
2006年 获日本筑波大学医科学专攻硕士学位（医学）
2010年 获日本筑波大学分子情报生体防御医学专攻博士学位（医学）
工作经历:
2009-2010年 JSPS（日本学术振兴会）特別研究员DC2
2010-2011年 JSPS（日本学术振兴会）博士研究员PD
2012年-至今 哈尔滨工业大学生命科学与技术学院副教授
Personal Profile
Education:
Mar 2010 University of Tsukuba (Japan) Molecular Intelligence and Biological Defence Medicine PhD
Mar 2006 University of Tsukuba (Japan) Medical Science Master
Jul 2000 Jilin University (China) Clinical Medicine Bachelor
Work Experience:
May 2012 - present Harbin Institute of Technology, School of Life Sciences and Technology Associate Professor
Apr 2010 - Mar 2011 JSPS (Japan Society for the Promotion of Science) Doctoral Researcher PD
Apr 2009 - Mar 2010 JSPS(Japan Society for the Promotion of Science) Special Research Fellow DC2
研究方向和领域
斑马鱼疾病模型
Zebrafish disease models
生物医学工程
Biomedical Engineering
毒理学
Toxicology
研究内容
1. 纳米材料的生物医学应用：
荧光纳米材料物的医学应用是当今的研究热点，特别是在生物成像和肿瘤介入治疗等方面。我做的主要工作是：制备装载复合型多模态纳米医用材料，用于重要疾病的检测及治疗。近年，先后开发了具有抗氧化性、高铁离子敏感性、抗菌性、以及抗肿瘤性的荧光碳量子点；核磁/超声引导的光热以及靶向复合型多模态荧光纳米材料。
2. Nrf2抗氧化信号通路与退行性疾病：
环境因素与多种疾病密切相关。Nrf2系统能对多种环境因子做出应答，激活抗氧化蛋白酶和第II相解毒酶等异物代谢酶的活性，使有害物质代谢排出体外，减缓对机体的损伤。我做的主要工作是：探究Nrf2系统在骨质酥松、高脂血症、动脉硬化、脂肪肝、肿瘤等疾病中的作用机制。
3. 斑马鱼疾病模型与毒理学平台建设:
斑马鱼易饲养，产卵量大，体外受精，胚胎透明，可以实现发育过程活体观察以及荧光实时监测，是毒理学研究的最佳模型。此外斑马鱼饲养成本低，性成熟周期短，受精卵体积大易于基因编辑和显微操作，与哺乳类动物基因保守率高，是人类疾病的理想模型。我做的主要工作是：建立了斑马鱼毒理学评价体系，对环境毒性、药物毒性、以及纳米材料毒性从急性/亚急性/慢性毒性、胚胎毒性、生殖毒性、心血管/肝脏/肾脏/神经/血液/胃肠道等方面进行系统性评价。建立了骨质酥松，高脂血症，糖尿病，脂肪肝等人类疾病模型，用于病理研究与药物筛选。
Research Interests
1. Biomedical applications of nanomaterials
Medical applications of fluorescent nanomaterials are a hot research topic today, especially in bio-imaging and tumour intervention. The main work I have done is to prepare loaded composite multimodal medical nanomaterials for the detection and treatment of major diseases. In recent years, we have developed fluorescent carbon quantum dots with antioxidant properties, high ferric ion sensitivity, antibacterial properties, and antitumour properties. NMR/ultrasound-guided photothermal and targeted composite multimodal fluorescent nanomaterials have also been developed.
2. Nrf2 antioxidant signalling pathways and degenerative diseases
The Nrf2 system responds to a variety of environmental factors, including the activation of foreign body metabolizing enzymes such as antioxidant proteases and phase II detoxification enzymes. By metabolising harmful substances out of the body, damage to the organism is mitigated. The main work I have done is to investigate the mechanism of action of the Nrf2 system in diseases such as osteoporosis, hyperlipidaemia, atherosclerosis, fatty liver and tumours.
3. Zebrafish disease model and toxicology platform construction
Zebrafish are the best model for toxicology research because of their ease of rearing, large spawning capacity, in vitro fertilisation and transparent embryos, which allow in vivo observation of developmental processes and real-time monitoring of fluorescence. In addition, zebrafish are an ideal model for human disease because of their low rearing costs, short sexual maturation cycle, large fertilized egg size for easy gene editing and microscopic manipulation, and high genetic conservation rate with mammals. The main work I have done is to establish a toxicological evaluation system for zebrafish, with systematic evaluation of environmental toxicity, drug toxicity, and nanomaterial toxicity in terms of cardiovascular, hepatic, renal, neurological, hematological, and gastrointestinal tracts for acute, subacute, and chronic toxicity, embryotoxicity, and reproductive toxicity. Human disease models such as osteoporosis, hyperlipidaemia, diabetes and fatty liver have been developed for pathological studies and drug screening.
研究成果
学术论文：
1. Fu R.P., Li B.S., Shao C.L., Li L.*, Liu Z.G., Shen A.D., Crystal plane selective adsorption and photogenerated carrier transfer between the SnS2 nanoparticles and AuNCs. Colloid and Interface Science Communications, 2021, https://doi.org/10.1016/j.colcom.2021.100499. (通讯作者) IF: 4.914
2. Fu R.P., Yu L.D., Li B.S.*, Li L.*, Liu Z.G.*, and Shen A.D., Longitudinal Dipole Modes of AuNRs for Photocatalytic Enhancement of Ultrathin Rutile TiO2 Nanosheets. J. Elect. Marter. 2020, 49: 5478–5487. (通讯作者) IF: 1.774
3. Li L., Gu N., Dong H.J.*, Li B.S.*, Kenneth T.V.G. Analysis of the effects of acoustic levitation to simulate the microgravity environment on the development of early zebrafish embryos. RSC Advances. 2020, 10: 44593-44600. IF: 3.361
4. Hu H.#, Zhang B.#, Li L.#, Guo Q, Yang D, Wei X, Fan X, Liu J, Wu Q, Oh Y, Feng Y, Chen K, Wang C, Hou L, Gu N*. The toxic effects of titanium dioxide nanoparticles on plasma glucose metabolism are more severe in developing mice than in adult mice. Environ Toxicol. 2019, 35(4):443-456. Nov 26. (共同一作) IF: 2.649
5. Hu H., Fan X., Yin Y., Guo Q., Yang D., Wei X., Zhang B., Liu J., Wu Q., Oh Y., Chen K., Feng Y., Hou L.*, Li L.*, Gu N.*. Mechanisms of titanium dioxide nanoparticle-induced oxidative stress and modulation of plasma glucose in mice. Environ Toxicol. 2019, 34(11):1221-1235. (通讯作者) IF: 2.649
6. Wei X. J., Li L.*, Liu J. L., Yu L. D., Li H. B., Cheng F., Yi X. T., He J. M.* and Li B. S.*. Green Synthesis of Fluorescent Carbon Dots from Gynostemma for Bioimaging and Antioxidant in Zebrafish. ACS Applied Materials & Interfaces, 2019, 11(10):9832-9840. (通讯作者) IF：9.229
7. Wang H.B.#, Chen H.Y.*#, Li L.#, Wang Y.F., Su L.X., Bian W.P., Li B.S.*, and Fang X.S.*. High Responsivity and High Rejection Ratioof Self-Powered Solar- Blind Ultraviolet Photodetect or Basedon PEDOT: PSS/β-Ga2O3 Organic/Inorganic p−n Junction. J. Phys. Chem. Lett. 2019, 10, 6850-6856. (共同一作) IF: 7.329
8. Wang Y.F.#, Li L.#, Wang H.B., Su L.X., Chen H.Y.*, Bian W.P, Ma J.G., Li B.S.*, Liu Z.G. and Shen A.D.. An ultrahigh responsivity self-powered solar-blind photodetector based on a centimeter-sized β-Ga2O3/polyaniline heterojunction. Nanoscale. 2020, 12, 3:1406-1413. (共同一作) IF: 6.97
9. Mukaigasa K.#, Tsujita T.#, Nguyen V. T.#, Li L.#, Yagi H., Fuse Y., Nakajima-Takagi Y., Kato K., Yamamoto M. and Kobayashi M.*. Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish. PNAS. 2018, 115, 11:2758-2763. (共同一作) IF：9.504
10. 刘毅，李丽*，程磊，吴琼，李炳生. 基于模式生物斑马鱼Nrf2的相关研究进展. 现代生物医学进展, 2018 18, 6:191-194. (通讯作者). IF：0.633
11. 李爽, 李丽*，魏力军, 吴琼, 李炳生. 氧化损伤和微重力致骨质疏松症的研究进展. 现代生物医学进展, 2018 18, 7:1181-1184. (通讯作者). IF：0.633
12. Song D. Y.#, Li L.#, Li B. S.*, Sui Y. and Shen A. D.*. Band gap engineering of N-alloyed Ga2O3 thin films. AIP Advances, 2016 6, 6:065016. (共同一作). IF：1.653
13. 邓帅, 李雨珊, 段研芳, 李丽*, 安利民, 李炳生, 吴琼, 孙再成. 荧光碳点在脊椎类模式动物斑马鱼中的活体成像与毒理学研究. 发光学报, 2015 36, 4:485-490. (通讯作者). IF：0.943
14. Tsujita T.#, Li L.#, Nakajima H., Iwamoto N., Nakajima-Takagi Y., Ohashi K., Kawakami K., Kumagai, Y., Freeman B. A., Yamamoto M., Kobayashi M.*. Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish. Genes Cells 2011, 16:46-57. (共同一作). IF：2.952.
15. Kobayashi M.*, Li L., Iwamoto N., Nakajima-Takagi Y., Kaneko H., Nakayama Y., Eguchi M., Wada Y., Kumagai Y., Yamamoto M. The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol. Cell. Biol. 2009, 29(2):493-502. IF：6.057
16. Li L., Kobayashi M.*, Kaneko H., Nakajima-Takagi Y., Nakayama Y., Yamamoto M. Molecular Evolution of Keap1: two keap1 molecules with distinctive intervening region structures are conserved among fish. J. Biol. Chem. 2008, 283(6): 3248-3255. IF：5.328.
授权专利：
1. 一种抗菌防紫外光隐形眼镜的制备方法, ZL 201511009337.X 李丽，宋冬雨，单崇新，李炳生20180130
2. 热氧化ZnN：III族元素制备p-型氧化锌的方法ZL 201510658463.1 李丽，李炳生，王月飞，宋冬雨20180703
3. 一种以绞股蓝为碳源制备荧光碳点的方法，ZL201710758451.5 李丽，魏新晶，贺金梅，余立冬，李炳生，陈洪宇，宋冬雨 20201117
开设的课程
发育生物学，研究生必修
分子生物技术创新实验，研究生选修
疾病与分子病理学（国际共建课程），研究生选修
生物医学基础，本科生选修
本科生创新实验，全校本科生选修
医学基础，研究生选修
生物学特色实验课，本科生专业必修
Developmental Biology, compulsory for graduate students
Experiments in Molecular Biotechnology Innovation, postgraduate elective
Disease and Molecular Pathology (International Co-curriculum), postgraduate elective
Fundamentals of Biomedicine, undergraduate elective
Innovative Undergraduate Experiments, undergraduate students
Fundamentals of Medicine, postgraduate elective
Specialised Biology Laboratory Course, compulsory for undergraduate majors
教师个人主页链接
http://homepage.hit.edu.cn/lilili
