联系方式
邮箱：kigo@hit.edu.cn
个人简介
1987 -1992年：哈尔滨医科大学 临床医学学士
1997 -1998年：日本国立新泻大学 生物研究生
1998 -2000年：日本国立新泻大学 生体机能专攻硕士
2000 -2003年：日本国立新泻大学 生物圈科学博士
2003 -2006年：日本东京农业大学 发育生物学研究员（博士后）
2006年-至今：哈尔滨工业大学 发育生物学教授
Personal Profile
1987 - 1992 Harbin Medical University, Clinical Medicine, Bachelor
1997 - 1998 Niigata University, Biology, Graduate
1998 - 2000 Niigata University, Master
2000 - 2003 Niigata University, Ph. D
2003 - 2006 Tokyo Agricultural University, Developmental Biology, researcher (postdoctoral) ,
2006 - present, Harbin Institute of Technology, Developmental Biology, professor
研究方向和领域
表观遗传学
Epigenetics
基因编辑技术
CRISPR/Cas9 gene-editing
肿瘤的靶向治疗
Targeted therapy for tumors
研究内容
主要研究哺乳动物及人的表观遗传机制。包括CpG岛的预测及DNA甲基化分析；RNA的甲基化和乙酰化修饰在胚胎发育和肿瘤发育过程中的作用机制；基于基因编辑技术的超级增强子在胚胎发育和肿瘤发育过程中的作用机制研究。
Research Interests
Mainly research the epigenetic mechanism of mammals and humans. Including CpG island prediction and DNA methylation analysis; RNA methylation and acetylation modification in embryonic development and tumor development process; the mechanism of super-enhancer during embryonic development and tumor development based on gene editing technology.
研究成果
1. m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling. Liu, Xin; He, Hongjuan; Zhang, Fengwei; Hu, Xin; Bi, Fanqi; Li, Kai; Yu, Haoran; Zhao, Yue; Teng, Xiangqi; Li, Jiaqi; Wang, Lihong; Zhang, Yan*; Wu, Qiong*. Cell Death & Disease, 2022, 13(5): 483.
2. Identification of a Five-miRNA Signature for Diagnosis of Kidney Renal Clear Cell Carcinoma. Zhao, Enyang; Li, Xuedong; You, Bosen; Wang, Jinpeng; Hou, Wenbin; Wu, Qiong*. Frontiers in Genetics, 2022, 13: 857411.
3. EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2.Shuang Cui , Qiong Wu*, Ming Liu, Mu Su, ShiYou Liu, Lan Shao, Xiao Han and Hongjuan He*.Cell Death and Disease _2021 Mar 12;12(3):264.
4. A Novel Approach to Identify Enhancer lincRNAs by Integrating Genome, Epigenome, and Regulatome.Liu, Hui; Jiang, Tiantongfei; Wang, Shuyuan; Chen, Xiang; Jin, Xiaoyan; Wang, Qi; Li, Xinhui; Yin, Jiaqi; Shao, Tingting*; Li, Yongsheng*; Xu, Juan*;Wu, Qiong*. Frontiers in Bioengineering and Biotechnology, 2019, 7: 427.
5. Baicalin inhibits breast cancer development via inhibiting I kappa B kinase activation in vitro and in vivo. Gao Yang; Liu Hui; Wang Hongzhi; Hu Hailong; He Hongjuan; Gu Ning; Han Xiao; Guo Qian; Liu Dong; Cui Shuang; Shao Hongjiang; Jin Chengjun; Wu Qiong*. nternational Journal of Oncology, 2018, 53(6): 2727-2736.
6. Highly fluorescent hyperbranched BODIPY-based conjugated polymer dots for cellular imaging. Du R, Cui S, Sun Z, Liu M, Zhang Y*, Wu Q*, Wu C, Guo F, Zhao L. Chem Commun (Camb). 2017 Jul 27;53(61):8612-8615.
7. Computational identification of putative lincRNAs in mouse embryonic stem cell.Liu, Hui; Lyu, Jie; Liu, Hongbo; Gao, Yang; Guo, Jing; He, Hongjuan; Han, Zhengbin; Zhang, Yan; Wu, Qiong*.Scientific Reports, 2016, 6: 34892.
8. Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer. Wei J, Li G, Zhang J, Zhou Y, Dang S, Chen H, Wu Q*, Liu M*. Oncotarget. 2016 Sep 20;7(38):62547-62558.
9. Target Delivery of a Novel Antitumor Organoplatinum(IV)-Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo. Sun T, Cui W, Yan M, Qin G, Guo W, Gu H, Liu S*, Wu Q*. Adv Mater. 2016 Sep;28(34):7397-404.
10. Aquaporin-1, a New Maternally Expressed Gene, Regulates Placental Development in the Mouse. Guo J, He H, Liu H, Liu Q, Zhang L, Liu B, Sugimoto K, Wu Q*. Biol Reprod. 2016 Aug;95(2):40.
11. Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct. Guo J, He H, Liu Q, Zhang F, Lv J, Zeng T, Gu N, Wu Q*. Mol Cells. 2015 Oct;38(10):859-65.
12. Expression patterns of long noncoding RNAs from Dlk1-Dio3 imprinted region and the potential mechanisms of Gtl2 activation during blastocyst development. Han Z, Yu C, Tian Y, Zeng T, Cui W, Mager J, Wu Q*. Biochem Biophys Res Commun. 2015 Jul 31;463(3):167-73.
13. MiR-1188 at the imprinted Dlk1-Dio3 domain acts as a tumor suppressor in hepatoma cells.Cui W, Huang Z, He H, Gu N, Qin G, Lv J, Zheng T, Sugimoto K, Wu Q*. Mol Biol Cell. 2015 Apr 15;26(8):1416-27.
14. DNA methylation dynamics of a maternally methylated DMR in the mouse Dlk1-Dio3 domain.Zeng TB, He HJ, Han ZB, Zhang FW, Huang ZJ, Liu Q, Cui W, Wu Q*.FEBS Lett. 2014 Dec 20;588(24):4665-71.
15. Identification of 4438 novel lincRNAs involved in mouse pre-implantation embryonic development.Lv J, Liu H, Yu S, Liu H, Cui W, Gao Y, Zheng T, Qin G, Guo J, Zeng T, Han Z, Zhang Y, Wu Q*. Mol Genet Genomics. 2015 Apr;290(2):685-97..
16. Identification and characterization of long intergenic non-coding RNAs related to mouse liver development.Lv J, Huang Z, Liu H, Liu H, Cui W, Li B, He H, Guo J, Liu Q, Zhang Y, Wu Q*.Mol Genet Genomics. 2014 Dec;289(6):1225-35.
17. MetaImprint: an information repository of mammalian imprinted genes.Wei Y, Su J, Liu H, Lv J, Wang F, Yan H, Wen Y, Liu H, Wu Q*, Zhang Y*.Development. 2014 Jun;141(12):2516-23.
18. DevMouse, the mouse developmental methylome database and analysis tools.Liu H, Zhu R, Lv J, He H, Yang L, Huang Z, Su J, Zhang Y, Yu S, Wu Q*. Database (Oxford). 2014 Jan 9;2014:bat084.
19. Neural-specific expression of miR-344-3p during mouse embryonic development.Liu Q, He H, Zeng T, Huang Z, Fan T, Wu Q*. J Mol Histol. 2014 Aug;45(4):363-72.
20. Dynamic expression pattern of Pde4d and its relationship with CpG methylation in the promoter during mouse embryo development.Huang Z, Han Z, Cui W, Zhang F, He H, Zeng T, Sugimoto K, Wu Q*.Biochem Biophys Res Commun. 2013 Nov 29;441(4):982-7.
21. Spatiotemporal expression of retrogene–host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells。Huang Zhijun, Han Zhengbin, Zhang Fengwei, He Hongjuan, Yu Shihuan,Wu Qiong*. Acta Histochem. 2014 Mar;116(2):312-8.
22. Expression analysis of AK003491, an imprinted noncoding RNA, during mouse development. Zeng TB, He HJ, Zhang FW, Han ZB, Huang ZJ, Liu Q, Wu Q*. Genes Genet Syst. 2013;88(2):127-33.
23. Quantitative epigenetic co-variation in CpG islands and co-regulation of developmental genes. Liu H, Chen Y, Lv J, Liu H, Zhu R, Su J, Liu X, Zhang Y, Wu Q*. Sci Rep. 2013 Sep 3;3:2576.
24. Identification and Characterization of Long Non-Coding RNAs Related to Mouse Embryonic Brain Development from Available Transcriptomic Data.Lv J, Cui W, Liu H, He H, Xiu Y, Guo J, Liu H, Liu Q, Zeng T, Chen Y, Zhang Y, Wu Q*. PLoS One. 2013;8(8):e71152.
25. Lv, Jie; Liu, Hongbo; Huang, Zhijun; Su, Jianzhong; He, Hongjuan; Xiu, Youcheng; Zhang, Yan; Wu, Qiong*. Long non-coding RNA identification over mouse brain development by integrative modeling of chromatin and genomic features Nucleic Acids Research, 41(22), pp 10044-10061, 2013/12.
26. Expression and imprinting analysis of AK044800, a transcript from the Dlk1-Dio3 imprinted gene cluster during mouse embryogenesis.Han Z, Liu Q, Huang Z, Cui W, Tian Y, Yan W, Wu Q*.Mol Cells. 2013 Apr;35(4):285-90.
27. miR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a.Qi L, Hongjuan H, Ning G, Zhengbin H, Yanjiang X, Tiebo Z, Zhijun H, Qiong W*.FEBS Lett. 2013 Mar 18;587(6):775-81.
28. Expression patterns of ubiquitin conjugating enzyme UbcM2 during mouse embryonic development. Xing Yanjiang, He Hongjuan, Gu Tiantian, Zhang Yan, Huang Zhijun, Wu Qiong*. Gene Expr. 2012;15(4):163-70.
29. Conservation of genomic imprinting at the NDN, MAGEL2 and MEST loci in pigs.Zhang FW, Han ZB, Deng CY, He HJ, Wu Q*.Genes Genet Syst. 2012;87(1):53-8.
30. Trmt112 gene expression in mouse embryonic development.Gu T, He H, Zhang Y, Han Z, Hou G, Zeng T, Liu Q, Wu Q*.Acta Histochem Cytochem. 2012 Apr 26;45(2):113-9.
31. Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination factor (MTERF) family.Xu Q, Zhang F, He H, Xu S, Li K, Liu S, Li Y, Wu Q*. Genes Genet Syst. 2011;86(4):269-75.
32. DiseaseMeth: a human disease methylation database. Jie Lv1,2, Hongbo Liu1, Jianzhong Su1, Xueting Wu1, Hui Liu1, Boyan Li1, Xue Xiao1,Fang Wang1, Qiong Wu2,* and Yan Zhang1,* NUCLEIC ACIDS RESEARCH卷: 40期: D1页: D1030-D1035
33. Spatiotemporal expression pattern of Mirg, an imprinted non-coding gene, during mouse embryogenesis.Han Z, He H, Zhang F, Huang Z, Liu Z, Jiang H, Wu Q*. J Mol Histol. 2011 Oct 29.
34. Expression of macro non-coding RNAs Meg8 and Irm in mouse embryonic development.Gu T, He H, Han Z, Zeng T, Huang Z, Liu Q, Gu N, Chen Y, Sugimoto K, Jiang H, Wu Q*. Gene Expr. 2012;15(4):163-70.
35. Imprinting and expression analysis of a non-coding RNA gene in the mouse Dlk1-Dio3 domain.Zhang FW, Zeng TB, Han ZB, He HJ, Chen Y, Gu N, Jiang HJ, Wu Q*. J Mol Histol. 2011 Aug;42(4):333-9.
36. Expression patterns of imprinted gene Inpp5f-v3 during mouse brain development.Yan C, Hongjuan H, Yanjiang X, Zhengbin H, Kai L, Fengwei Z, Jing H, Qiong W*.J Mol Histol. 2011 Apr;42(2):167-73.
37. Molecular cloning, mRNA expression and imprinting status of PEG3, NAP1L5 and PPP1R9A genes in pig.Zhang FW, Deng CY, He HJ, Gu N, Han ZB, Chen Y, Wu Q*. Genes Genet Syst. 2011;86(1):47-52.
38. Expression of non-coding RNA AB063319 derived from Rian gene during mouse development.Gu T, He H, Xing Y, Liu Q, Gu N, Kenkichi S, Jiang H, Wu Q*.J Mol Histol. 2011 Apr;42(2):105-12.
39. Mengya Gao, Qi Liu, Zhuo Gao, Jing Hou, Fanzhi Kong, Fengwei Zhang and Qiong Wu* Expression of PRELI Domain Containing 2 Gene (PRELID2) During Mouse Embryonic Development. J Mol Hist 2009 40: 227-233
40. Kawahara M, Wu Q, Ferguson-Smith AC, Kono T. Appropritate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term.FEBS Lett. 2007 Nov 13;581(27):5178-84.
41. Wu Q, Kawahara M, Kono T.Synergistic Role of Igf2 and Dlk1 in Fetal Liver Development and Hematopoiesis in Bi-Maternal Mice. J Reprod Dev. 2008 Mar 13.
42. Kawahara M, Wu Q, Takahashi N, Morita S, Yamada K, Ito M, Ferguson-Smith AC, Kono T.High-frequency generation of viable mice from engineered bi-maternal embryos.Nat Biotechnol. 2007 Sep;25(9):1045-50.
43. Manabu Kawahara, Qiong Wu, Yukio Yaguchi, Anne C. Ferguson-Smith, Tomohiro Kono. Complementary roles of genes regulated by two paternally methylated imprinted regions on chromosomes 7 and 12 in mouse placentation.Hum Mol Genet. 2006;2869-2879.
44. Qiong Wu, Takuya Kumagai, Manabu Kawahara, Hidehiko Ogawa, Hitoshi Hiura,Yayoi Obata, Riya Takano and Toohiro Kono. Regulated expression of two sets of paternally imprinted genes is necessary for mouse parthenogenetic development to term. Reproduction. 2006;131:481-488.
45. Kono T, Obata Y, Wu Q, Niwa K, Ono Y, Yamamoto Y, Park ES, Seo JS, Ogawa H. Birth of parthenogenetic mice that can develop to adulthood.Nature. 2004; 428: 860-864. （IF: 26.601，
开设的课程
表观遗传学
Epigenetics
教师个人主页链接
http://homepage.hit.edu.cn/wuqiong
