研究方向一:新型生物活性水凝胶用于肿瘤逆转治疗
胚胎组织的微环境可通过表遗传学机制使肿瘤细胞逆向转化为表型正常的细胞,这一过程主要是通过抑制肿瘤细胞中不受调控的nodal信号蛋白的过度表达实现的。针对这样的发现,本课题组研制出一种新型的生物活性水凝胶材料用于肿瘤的逆向转化治疗,为肿瘤的治疗开辟了新的途径。
研究方向二:生物活性水凝胶用于心肌梗死修复
心肌梗死是一种主要的心血管疾病,并在在2013年的统计中发现,其是致死率最高的疾病之一。由于极为有限的心肌再生潜力和心脏供体器官的严重匮乏,使得心肌梗死的治疗措施极为有限。针对该问题,本课题组研制出一种新型水凝胶缓释系统用于心肌梗死的治疗研究,为心肌梗死的治愈提供新的途径。
研究方向三:中枢神经损伤修复
中枢神经损伤由于神经元难以再生成为影响人类生活健康的重要疾病,干细胞医学为治疗中枢神经损伤提供了新的解决策略,干细胞移植成活率和分化有效率极低严重阻碍了干细胞治疗。本课题组采用生物活性水凝胶提高移植成活率,采用新型缓释小分子药物和固定化AbCripto-1及mi-RNA提高干细胞有效分化率。
研究方向四:航天与空间生命科学研究
在空间生物学和医学基础研究中重点关注空间细胞生物学、辐射生物学和磁生物学效应等基本科学问题的研究。
承担的主要科研项目
1.用于肿瘤逆转的新型可注射生物活性水凝胶材料的研究,国家自然科学基金青年项目2010年10月 2012年12月 负责人21
2.透明质酸水凝胶用肿瘤细胞逆转的研究,教育部留学归国启动基金 39批 2011年1月 2013年12月 负责人 4
3. Bio-Fabrication of Live Cell Scaffolds for Spinal Cord Injury (SCI) Repair加拿大SHRF基金国际合作项目 2012年1月 2013年12月 国际合作
4.国家自然科学基金项目,中加健康研究合作计划项目:包覆活细胞的可注射水凝胶用于心肌梗死治疗的研究,批准号:81361128005,经费额度:100万,起止年月:2014年1月至2016年12月,负责人。
5.国家重点实验室开放课题, SMFA10k02,模拟失重效应对心肌离子通道影响的研究 2011.1-2012.12, 航天医学基础与应用国家重点实验室,负责,结题。 6
6.黑龙江省博士后启动基金,用于肿瘤逆转的新型可注射凝胶的研究, 2010-2012,黑龙江省,负责,结题。3
7.肿瘤生物学国家重点实验室开放课题,胃癌肿瘤细胞逆转治疗的研究,2011-2012 负责,结题。
近期发表论文情况:
1. Guorui Jin, Yong Li, Molamma P Prabhakaran, Weiming Tian* and Seeram Ramakrishna in vitro &in vivo evaluation of the wound healing capability of electrospungelatin/PLLCL nanofibers Journal of Bioactive and Compatible Polymers65279; 2014:1�18
2. Andrew J. Sawyer , Weiming Tian , Jennifer K. Saucier-Sawyer , Paul J. Rizk ,
W. Mark Saltzman , Ravi V. Bellamkond, Themis R. Kyriakides. The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation Biomaterials 35 (2014) 6698-6706
3. Yan Hongji, He Yue, Yin Yanbin, Wang Xiumei, Xiongbiao Chen, Song Zhang, Cui Fuzhai, Yu Li, Yongzhan Nie,Weiming Tian*. Self-assembled monolayers with different chemical group substrates for the study of MCF-7 breast cancer cell line behavior. Biomedical Materials, 8(3):035008. 2013
4. Xiuping Bai, Rui Fang, Song Zhang, Xinli Shi, Zeli Wang, Xiongbiao Chen, Jing Yang, Xiaolu Hou, Yongzhan Nie, Yu Li, and Weiming Tian*. self-cross-linkable hydrogels composed of partially oxidized alginate and gelatin for myocardial infarction repair. Journal of Bioactive and Compatible Polymers, 28 (2) 126-140,2013
5. Hong-xia Zheng*, Wei-ming Tian*, Hong-ji Yan, Hua-dong Jiang, Shan-shan Liu, Lei Yu, Fang Han, Li-jun Wei, Xiong-biao Chen , Yu Li. Expression of estrogen receptor α in human breast cancer cells regulates mitochondrial oxidative stress under simulated microgravity. Advances in Space Research 49(10):1432-1440,2012
6.Zheng, Hong-xia, Liu, Shan-shan, Tian, Wei-ming, Yan, Hong-ji, Zhang, Yao, *Li, Yu A three-dimensional invitro culture model for primary neonatal rat ventricular myocytes. Current Applied Physics, 12(3):826�833,2012
7. Hongxia Zheng*, Weiming Tian*, Hongji Yan, Lei Yue, Yao Zhang, Fengtong Han, Xiongbiao Chen and Yu Li. Rotary culture promotes the proliferation of MCF-7 cells encapsulated in three-dimensional collagen-alginate hydrogels via activation of ERK1/2-MAPK pathway. Biomedical Materials 7,015003, 2012(* co-first author)
8. Weiming Tian, Andrew Sawyer, Feriha B. Kocaoglu, Themis R. Kyriakides. (2011) Astrocyte-Derived Thrombospondin-2 Is Critical for the Repair of the Blood-Brain Barrier. The American Journal of Pathology 179(2)860-868. (IF: 5.224)
9. X. P. Bai, H. X. Zheng, R. Fang, T. R. Wang, X. L. Hou, Y. Li, X. B. Chen, W. M. Tian*, 2011, “Fabrication of Engineered Heart Tissue Grafts from Alginate/Collagen Barium Composite Microbeads,” Biomedical Materials, 6(4): 045002, 2011
10. Tian W.M., Kyriakides T. R. 2009. MMP-9 deficiency leads to prolonged foreign body response in the brain associated with increased IL-1β levels and leakage of the blood brain barrier. Matrix Biology. 28, 148-159. (IF: 3.328)
11.Tian W. M.; Kyriakides T. R. 2009. Thrombospondin 2-null mice display an altered brain foreign body response to polyvinyl alcohol sponge implants. Biomedical materials.4, 415010-1513. (IF: 2.467)
12. Maclauchlam S, Skokos E, Agah A, Zeng JM, Tian WM, Davidson JM, Boristein P and Kyriakides RK. Enhanced angiogenesis and reduced contraction in Thrombospodin-2-null wounds is associated with increased levels of matrix metalloproteinase 2 and 9 and soluable VEGF. Journal of Histochemistry and cytochemistry. vol. 57 no. 4 301-313 (IF: 2.381)
13. Krady, M. M., Zeng J., Yu J., Lauchlan S. M., Skokos E. A., Tian, W.M., Bornstein, P., Sessa W.C., Kyriakides T.R. 2008. Thrombospondin-2 modulates extracellular matrix remodeling during physiologic angiogenesis. American journal of pathology.173:879-891 (IF: 5.224)
14.Wei, Y.T., Tian, W.M., Yu, X., Cui, F.Z., Hou, S.P., Xu, Q.Y., and Lee, I.S. 2007. Hyaluronic acid hydrogels with IKVAV peptides for tissue repair and axonal regeneration in an injured rat brain. Biomedical Materials 2:S142-S146. (IF: 2.467)
15. Hou, S., Tian, W.M., Xu, Q., Cui, F., Zhang, J., Lu, Q., and Zhao, C. 2006. The enhancement of cell adherence and inducement of neurite outgrowth of dorsal root ganglia co-cultured with hyaluronic acid hydrogels modified with Nogo-66 receptor antagonist in vitro. Neuroscience 137:519-529. (IF: 3.215)
16.Cui, F.Z., Tian, W.M., Hou, S.P., Xu, Q.Y., and Lee, I.S. 2006. Hyaluronic acid hydrogel immobilized with RGD peptides for brain tissue engineering. Journal of Materials Science-Materials in Medicine 17:1393-1401. (IF: 2.325)
17.Zhao, B.H., Tian, W.M., Feng, H.L., Lee, I.S., and Cui, F.Z. 2005. Effects of RGD peptide grafting to titanium dental implants on the adhesion of human gingival fibroblasts and epithelial cells. Current Applied Physics 5:407-410. (IF: 1.740).
18.Tian, W.M., Zhang, C.L., Hou, S.P., Yu, X., Cui, F.Z., Xu, Q.Y., Sheng, S.L., Cui, H., and Li, H.D. 2005. Hyaluronic acid hydrogel as Nogo-66 receptor antibody delivery system for the repairing of injured rat brain: in vitro. J Controlled Release 102:13-22. (IF: 7.164)
19. Tian, W.M., Hou, S.P., Ma, J., Zhang, C.L., Xu, Q.Y., Lee, I.S., Li, H.D., Spector, M., and Cui, F.Z. 2005. Hyaluronic acid-poly-D-lysine-based three-dimensional hydrogel for traumatic brain injury. Tissue Engineering 11:513-525. (IF:4.636).
20.Hou, S.P., Xu, Q.Y., Tian, W.M., Cui, F.Z., Cai, Q., Ma, J., and Lee, I.S. 2005. The repair of brain lesion by implantation of hyaluronic acid hydrogels modified with laminin. Journal of Neuroscience Methods 148:60-70. (IF:2.100).
21. Zhang, C.L., Tian, W.M., and Cui, F.Z. 2005. Evaluation of resorbable barrier for preventing surgical adhesions. Current Applied Physics 5:411-416. (IF: 1.740).
22. Cui, F.Z., Tian, W.M., Fan, Y.W., Hou, S.P., Xu, Q.Y., and Lee, I.S. 2003. Cerebrum repair with PHPMA hydrogel immobilized with neurite-promoting peptides in traumatic brain injury of adult rat model. Journal of Bioactive and Compatible Polymers 18:413-432. (IF:2610)
23. TIAN Wei ming , XU Qun-yuan, FAN Yu-wei, CU I Fu-zhai, CAI Qing, ZHANG Jin-lu. 2005. Repair of murine brain injury by implantation of bioact ive hydrogel containing IKVAV peptide. Basic & Clinical Medicine 125(11):999-1003.( In Chinese)
已授权专利:
1.田维明,闫宏吉,李钰.一种用于肿瘤治疗的可注射生物活性水凝胶材料的制备方法,2013.9,中国,ZL201210164182.7
2.田维明,张建隆,李钰,郑红霞.一种用于地面模拟空间环境下心肌变化机制的三维类心肌组织的微球制备方法,2012.12, 中国,ZL201110061542.6
3.田维明,李钰,郑红霞. 一种用于研究模拟微重力效应的三维类骨组织的制备方法,2012.8,中国,ZL201110107352.3
4.田维明,李钰,房蕊,郑红霞.用于治疗心肌梗死的海藻酸钠-蛋白胶可注射凝胶材料及其制备方,2013.9, 中国,ZL201110103709.0
5.田维明,房蕊,李钰.缓释BIO/IGF 的复合水凝胶的制备方法及其应用,2012.12,中国,ZL201110442291.6
实验室成员构成及简介
联系电话:86-0451-86403484
E-mail: tianweiming@hit.edu.cn
2005年获清华大学博士学位,2005-2008年耶鲁大学博士后。中国空间学会会员,并担任生物医学材料、生物制造等国际期刊的审稿人。主要从事组织工程与生物材料研究,重点生物活性水凝胶在心肌组织工程和肿瘤逆转的研究,在空间生物学和医学基础研究中重点关注空间细胞生物学、辐射生物学和磁生物学效应等基本科学问题的研究。先后发表学术研究论文25篇,代表性论文发表在Tissue Engineering、American Journal of Pathology、Journal of Controlled Release、Matrix Biology和Biomedical Materials等国际专业杂志。获发明专利授权5项。实验室现有3名博士研究生,其中留学生2名(俄罗斯、伊朗),硕士研究生4人。
人才培养
实验室十分重视人才培养,培养学生科研、管理、学习能力。实验室学生中优秀毕业生2人,GE创新奖4人次,特等奖学金2人次。毕业生均匀有较好去向,其中3名学生海外留学深造;1名学生海外管理;1名同学任职天津大学,2名毕业生就职于生物医疗行业名企。