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施树良简历
发布人:系统管理员  发布时间:2012-05-09   浏览次数:2446

副教授/硕士生导师―施树良

专业: 细胞生物学

联系电话: 0451-86412863 

电子信箱:liangss@hit.edu.cn

通讯地址:哈尔滨工业大学437信箱

邮编:150001


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简历

1987-1991 东北师范大学   生物系 学士

1991-1994 哈尔滨师范大学 遗传学 硕士

1994-1999 哈尔滨医科大学 助教、讲师

1999-2000 日本京都大学医学研究科 访问学者

2000-2004 日本京都大学医学研究科 博士

2004-2005 日本京都大学医学研究科 分子肿瘤学研究室 assistant professor

2005年-今 哈尔滨工业大学 生命科学与技术学院   副教授


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研究方向:

主要研究细胞癌化的分子机理和信号传导。


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发表科研论文

1.         Rap1 mutants with increased affinity for the guanine-nucleotide exchange factor C3G. Shuliang Shi, Makoto Noda, Hitoshi Kitayama. Oncogene. 23 (2004): 8711-8719.

2.         Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK. J. Oh, D. W. Seo, T. Diaz, B. Wei, Y. Ward, Y. Morioka, S. Shi, H. Kitayama, C. Takahashi, M. Noda, W. G. Stetler- Stevenson. Cancer Research. 64(2004): 9062-9069.

3.         Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II. Jiegou Xu, Shuliang Shi, Naoya Matsumoto, Makoto Noda, Hitoshi Kitayama. Cell Signal. 19 (2007):1575-82

4.         A positive feedback mechanism of GTP-bound R-Ras on C3G-mediated activation of Rap1.  Shi Shuliang, Zhongjiang Gao, Yu Li, Yoko Morioka, Makoto Noda, Hitoshi Kitayama  CSCB (2007) Guang Zhou, Oral presentation

5.         The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts.Morioka Y, Monypenny J, Matsuzaki T, Shi S, Alexander DB, Kitayama H, Noda M. Oncogene. 28 (2009): 1454-1464

6.         a novel nuclear protein that is downregulated in multiple cancers and silenced by DNA methylation. Shan Wang, Yu Li, Fang Han, Jianran Hu, Lei Yue, Youtao Yu, Yubao Zhang, Jie He, Hongxia Zheng, Shuliang Shi, Xiaowei Fu, Hongjin Wu. Identification and characterization of MARVELD1. Cancer Letters. 282(2009):77-86

7.         Identification of mouse MARVELD1 as a microtubule associated protein that inhibits cell cycle progression and migration.Zeng F, Tian Y, Shi S, Wu Q, Liu S, Zheng H, Yue L, Li Y. Mol Cells. 2011, 31(3):267-74

8.         Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway.Liu SS, Chen XM, Zheng HX, Shi SL, Li Y. J Biomed Sci. 2011 Aug 17;18:58.

9.         小分子量G蛋白Rap2信号途径的生物学功能.沈春雯, 高忠江, 施树良.中国细胞生物学学报.2010, 32(1):17-23