应生命科学与技术学院黄志伟教授邀请，耶鲁大学Department of Molecular Biophysics and Biochemistry副教授Yong Xiong将于7月9日来我校开展学术交流，欢迎感兴趣的老师和同学积极参加！
报告题目：A structural biology view of HIVsuppression by host antiviral factors and viral immune evasion strategies
时 间：2015年7月9日（星期四）10:00
地 点：科学园2E栋405会议室
报 告 人：Yong Xiong
报告人简介：
Yong Xiong, AssistantProfessor of Department of MolecularBiophysics and Biochemistry, Yale University; 1990-1994, ModernApplied Physics Department, Tsinghua University; 1994-2000, Ph.D. in Biophysicswith Dr. Muttaiya Sundaralingam, The Ohio State University; 2000-2001, PostdoctoralAssociate with Dr. Muttaiya Sundaralingam, Chemistry Department, The Ohio StateUniversity; 2001-2006, Postdoctoral Associate with Dr. Thomas Steitz,Department of Molecular Biophysics & Biochemistry, Yale University; 2006-2011, Assistant Professor of MolecularBiophysics and Biochemistry, Yale University;2011 to present, Associate Professor of MolecularBiophysics and Biochemistry, Yale University.
His laboratory studies hostimmune responses to viral infections and cellualr DNA repair pathways. They usea variety of techniques, including X-ray crystallography, electron microscopy,biochemistry, and computational biology. They also develop new structural biologymethods.
Research Publications（2014-2015）
1. JiaX, Zhao, Q & Xiong Y (2015). HIVSuppression by Host Restriction Factors and Viral Immune Evasion. Curr.Opin. Struct. Biol. 31:106-14.
2. JiX & Xiong Y (2015). Two Tales(Tails) of SAMHD1 Destruction by Vpx. Cell HostMicrobe 17,425-427.
3. NguyenH, Yang H, Fribourgh J, Wolfe LS & XiongY (2015). Insights into Cullin-RING E3 ubiquitin ligase recruitment:Structure of the VHL�EloBC�Cul2 complex. Structure 23, 1-9. Epub Feb 5, 2015.
4. AlazamiAM et al., & Alkuraya FS (2015). Accelerating Novel Candidate GeneDiscovery in Neurogenetic Disorders Through Whole-Exome Sequencing ofPrescreened Multiplex Consanguineous Familie. Cell Reports 10, 148-61.Epub, Dec 31, 2014.
5. ZhaoQ, Xue X, Longerich S, Sung P & XiongY (2014). Structural Insights into 5' Flap DNA Unwinding and Incision bythe Human FAN1 Dimer. Nat. Commun. 5:5726 doi:10.1038/ncomms6726.
6. FribourghJ, Nguyen H, Matreyek KA, Alvarez FJD, Summers BJ, Dewdney TG, Aiken C, ZhangP, Engelman A & Xiong Y (2014).Structural Insight into HIV-1 Restriction by Myxovirus Resistance Protein 2(MxB). Cell Host Microbe 16, 627-638. Epub Oct 9, 2014.
7. Longerich S, Li J, Xiong Y, Sung P& Kupfer M (2014). Stress and DNA repair biology of the Fanconi anemiapathway. Blood 124, 2812-2819.Epub Sep 15, 2014.
8. JiX, Tang C, Zhao Q, Wang W & Xiong Y (2014) Structural basis of Cellular dNTP regulation by SAMHD1. Proc.Natl. Acad. Sci. USA. 111, E4305-E4314. Epub Sep 29, 2014.
9. UchilPD, Pawliczek T, Reynolds TD, Ding S, Hinz A, Munro J, Huang F, Floyd RW, YangH, Hamilton W, Bewersdorf J, Xiong Y,Calderwood DA & Mothes W (2014). TRIM15 is a focal adhesion protein thatregulates focal adhesion disassembly. J. Cell Sci. 1273928-42.
10. ShaheenR, Rahbeeni Z, Alhashem A, Faqeih E, Zhao Q, Xiong Y, Almoisheer A, Al-Qattan SM, Almadani HA, Al-Onazi N,Al-Baqawi BS, Saleh MA & Alkuraya FS (2014). Neu-Laxova syndrome, an inbornerror of serine metabolism, is caused by mutations in PHGDH. Am. J. Hum.Gen. 94: 898-904
11. PateliN, El Mouzan MI, Al-Mayouf SM, Adly N, Mohamed JY, Al Mofarreh MA, Ibrahim N, Xiong Y, Zhao Q, Al-Saleem KA &Alkuraya FS (2014). Study of Mendelian forms of Crohn's disease in Saudi Arabiareveals novel risk loci and alleles. Gut 124, 2812-2819.Epub Aug 21, 2014.
12. JiaX, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, Guatelli J & Xiong Y (2014). Structural Basis ofHIV-1 Vpu-Mediated BST2 Antagonism via Hijacking of the Clathrin AdaptorProtein Complex 1. eLife 3: e02362.
13. PatelN, Khan AO, Masnour A, Mohamed J, Al-Assiri A, Haddad R, Jia X, Xiong Y, Traboulsi E, Fowzan &Alkuraya FS (2014). Mutations in ASPH, Encoding Aspartyl β-Hydroxylase, CauseFacial Dysmorphism, Lens Dislocation, Anterior Segment Abnormalities,Spontaneous Filtering Blebs (FDLAB or Traboulsi Syndrome). Am. J. Hum.Gen. 94: 755-759.
14. AldahmeshMA, Li Y, Alhashem A, Anazi S, Alkuraya H, Al-Awaji A, Sakati S, Alkharashi A,Alzahrani S, Al Hazzaa SA, Xiong Y,Sun Z & Alkuraya FS (2014). IFT27, encoding a small GTPase component of IFTparticles, is mutated in a consanguineous family with Bardet-Biedl syndrome. Hum.Mol. Genet. 23: 3307-3315. Epub Jan 31, 2014.
15. FribourghJ, Nguyen H, Wolfe L, DeWitt DC, Zhang W, Yu XF, Rhoades E & Xiong Y (2014). CBFβ plays a criticalrole facilitating the assembly of the Vif-Cul5 E3 ubiquitin ligase. J.Virol. 88, 3309-19. Epub Jan 3, 2014.
16. ZhaoQ, Saro D, Sachpatzidis A, Singh RR, Schlingman D, Zheng X, Mack A, Tsai MS,Mochrie S, Regan L, Meetei AR, Sung P & Xiong Y (2014). MHF complex senses branched DNA via binding a pairof crossover DNA duplexes. Nat. Commun. 5:2987-98.
17. LiuC & Xiong Y (2014). ElectronDensity Sharpening as a General Crystallographic Technique. J. Mol. Biol. 426, 980-993. Epub Nov 21, 2013.
生命科学与技术学院
2015年7月8日
