应生命科学与技术学院李钰教授邀请，美国华盛顿大学医学院王小伟副教授将于11月5日来我校开展学术交流，欢迎感兴趣的老师和同学积极参加！
报告题目：MicroRNAs as Cancer Biomarkers and Potential Therapeutic Agents
时 间：11月5日（星期三）9:30
地 点：科学园2E栋411室
内容简介：
Our research is focused on a family of non-coding RNAs called microRNAs. Thousands of human protein-coding genes are regulated by microRNAs, and microRNAs may act as master regulators for many important biological pathways. In this talk, I'll present the translational aspect of microRNA research by introducing a few projects in our lab that are focused on using miRNA as biomarkers for predicting cancer outcome, as well as potential therapeutic agents for cancer treatment.
报告人简介：
Current Position: Assistant Professor of Cancer Biology and Biomedical Engineering, Department of Radiation Oncology, Washington University School of Medicine
Education:
2000: Ph.D. in Biochemistry, Tufts University School of Medicine, Boston
2000: MCP, Microsoft Certified Professional
1993: B.S. in Biochemistry, Nankai University, China
Publications (2012-2014):
* Corresponding author
1. Liu W, Gao G, Hu X, Wang Y, Schwarz JK, Chen JJ, Grigsby PW, Wang X* (2014) Activation of miR-9 by Human Papillomavirus in Cervical Cancer. Oncotarget, Epub ahead of print.
2. Wang X* (2014) Composition of seed sequence is a major determinant of microRNA targeting patterns. Bioinformatics 30(10):1377-1383.
3. Jiang Z, Liu W, Wang Y, Gao Z, Gao G, Wang X* (2013) Rational design of microRNA-siRNA chimeras for multi-functional target suppression. RNA 19(12):1745-1754.
4. Gao G, Gay HA, Chernock RD, Zhang TR, Luo J, Thorstad WL, Lewis JS, Wang X* (2013) A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma. Cancer 119(1):72-80.
5. Gao G, Chernock RD, Gay HA, Thorstad WL, Zhang TR, Wang H, Ma XJ, Luo Y, Lewis JS, Wang X* (2013) A novel RT-PCR method for quantification of human papillomavirus transcripts in archived tissues and its application in oropharyngeal cancer prognosis. International Journal of Cancer 132(4):882-90.
6. Volders PJ, Helsens K, Wang X, Menten B, Martens L, Gevaert K, Vandesompele J, Mestdagh P (2013) LNCipedia: a database for annotated human lncRNA transcript sequences and structures. Nucleic Acids Research 41(D1):D246-251.
7. Volders PJ, Helsens K, Wang X, Menten B, Martens L, Gevaert K, Vandesompele J, Mestdagh P (2013) LNCipedia: a database for annotated human lncRNA transcript sequences and structures. Nucleic Acids Research 41(D1):D246-251.
8. Chernock RD, Wang X, Gao G, Lewis JS Jr, Zhang Q, Thorstad WL, El-Mofty SK (2013) Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx. Modern Pathology, 26(2):223-31.
9. Hu Y, Sopko R, Foos M, Kelley C, Flockhart I, Ammeux N, Wang X, Perkins L, Perrimon N, Mohr SE (2013) FlyPrimerBank: An Online Database for Drosophila melanogaster Gene Expression Analysis and Knockdown Evaluation of RNAi Reagents. G3 (Bethesda) 3(9):1607-16.
10. Patel KR, Chernock RD, Zhang TR, Wang X, El-Mofty SK, Lewis JS Jr. (2013) Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus. Human Pathology 44(11):2385-92.
11. Oh JH, Wong HP, Wang X, Deasy JO (2012) A bioinformatics filtering strategy for identifying radiation response biomarker candidates. PLoS One. 7(6):e38870.
12. Wang X, Spandidos A, Wang H, Seed B (2012) PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update. Nucleic Acids Research 40(1):D1144-1149.
Issued Patent
Xiaowei Wang, Wang XH and Setterquist R (2010) Reverse transcription primers and methods of design. Patent Number: EP1957645B1.
Research Support
Active
1. NIH R01GM089784 (4/1/10-3/31/15), Role: PI, Title: Combined Computational and Experimental Analyses of Gene Regulation by MicroRNAs
2. NIH R21CA177902 (4/1/14-3/31/16), Role: PI, Title: MicroRNA Biomarkers for Cervical Cancer
3. BJH Foundation (6/1/14-5/31/15) Role: PI Title: Gene signature to predict metastasis in HPV-Positive oropharyngeal cancer
4. Radiation Oncology Invention Grant (1/1/2014-12/31/2014), Role: PI, Title: Design of Artificial Interference RNA for Multi-Functional Target Suppression
Completed
1. Radiation Oncology Invention Grant (1/1/2013-12/31/2013), Role: PI, Title: MicroRNA Biomarkers for Oropharyngeal Cancer Prognosis
2. Siteman Cancer Frontier Fund (1/1/12-12/31/12), Role: PI, Title: MicroRNA Expression Signatures to Predict Cervical Cancer Outcome
3. The Longer Life Foundation (10/1/09-9/30/10), Role: PI, Title: MicroRNA Expression Signatures to Predict Cervical Cancer Outcome
4. The American Cancer Society (1/1/09-12/31/09), Role: PI, Title: MicroRNA Expression Signatures to Predict Cervical Cancer Outcome
